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Oncolytics Biotech Inc. Announces Issuance of 25th U.S. Patent

Wednesday, December 12, 2007

Calgary -- Oncolytics Biotech Inc. ("Oncolytics") today announced that it has been granted U.S. Patent 7,306,902 entitled "Oncolytic Viruses as Phenotyping Agents for Neoplasms." The claims describe methods of diagnosing cancers with unknown phenotypes by using oncolytic viruses that selectively replicate in cancer cells with known phenotypes.

"Oncolytic viruses are selective for certain mutations in cancer cells," said Dr. Matt Coffey, Chief Scientific Officer of Oncolytics. "By using these viruses in tumour samples, we may be able to more accurately diagnose the various cancer phenotypes, ultimately leading to a more individualized approach to cancer treatment."

About Oncolytics Biotech Inc.

Oncolytics is a Calgary-based biotechnology company focused on the development of oncolytic viruses as potential cancer therapeutics. Oncolytics' clinical program includes a variety of Phase I and Phase II human trials using REOLYSIN, its proprietary formulation of the human reovirus, alone and in combination with radiation or chemotherapy. For further information about Oncolytics, please visit

This news release contains forward-looking statements, within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements, including among others, the Company's belief as to the importance of the issuance of this patent, the safety and efficacy of the reovirus, the Company's expectations as to the potential applications of the patented technology and other statements relating to anticipated developments in the Company's business and technologies, involve known and unknown risks and uncertainties that could cause the Company's actual results to differ materially from those in the forward looking statements. Such risks and uncertainties include, among others, the efficacy of REOLYSIN as a cancer treatment, the success and timely completion of clinical studies and trials, uncertainties related to the research and development of pharmaceuticals and uncertainties related to the regulatory process. Investors should consult the Company's quarterly and annual filings with the Canadian and U.S. securities commissions for additional information on risks and uncertainties relating to the forward-looking statements. Investors are cautioned against placing undue reliance on forward-looking statements. The Company does not undertake to update these forward-looking statements.

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