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Vitro Develops Novel Reprogrammed Human Stem Cells and Files Patent

Wednesday, December 02, 2009

Golden, CO -- Vitro Diagnostics, Inc. (OTCBB: VODG), dba Vitro Biopharma, announced the filing of a new United States patent application entitled "POU5-F1 Expression in Human Mesenchymal Stem Cells" and the development of new technology related to generation of human induced pluripotent stem cells (iPS). IPS technology allows the use of reprogrammed adult cells to achieve properties of embryonic stem cells including the ability to differentiate into any type of cell in the body. IPS technology is subject to intense research because it may allow generation of stem cells with the primary properties of embryonic stem cells without sacrifice or use of embryos, thus avoiding ethical and religious controversies surrounding the use of embryonic stem cells.

Human iPS technology was originally reported in 2007 and evolved from increased understanding of the function of genetic factors controlling cellular fate and specific genes involved in the determination of "stemness," i.e., those genes whose expression result in classic stem cell properties. The original methods of iPS generation involved genetic engineering of human fibroblast (skin) cells to express elevated levels of four key genes. Vitro’s new technology involves elevated expression of a single gene called POU5-F1 (Oct3/4), which is considered a master regulatory element or gatekeeper of pluripotentiality. Such cells may be used to eventually generate iPS without use of genetic engineering, which is a key goal necessary for clinical application of iPS technology.

Dr. Jim Musick, Vitro’s CEO said, "We are pleased to announce development of our technology and cell lines related to generation of iPS cells. We hope that these products contribute to further development of iPS technology into viable clinical applications. Given this achievement, it may be possible to use banked cells from an individual patient to treat diseases such as diabetes, cancer, heart disease and several other conditions using specific processing of the banked cells to replace damaged, diseased, aged or otherwise non-functional cells. Such developments could usher a new age of regenerative medicine and contribute to tremendous reductions in the cost of medical care, a key goal of current health care reform."

About Vitro Diagnostics, Inc.

Vitro Diagnostics, Inc. dba Vitro Biopharma (OTCBB: VODG) (, known for "Harnessing the Power of Cells" especially various applications of adult stem cells, owns U.S. patents for production of FSH, a fertility drug, immortalization of cells, and adult stem cells. The Company also owns a pending U.S. patents regarding stem cell-based cancer treatments, generation of iPS cells and is continuously developing newly patentable cell lines and technologies. Vitro recently established a new high tech and regulatory compliant manufacturing, R&D and corporate facility in Golden, Colorado. We manufacture and sell "Tools for Stem Cell and Drug Development™," including human mesenchymal stem cells and derivatives, optimized media for sustained self-renewal, and products supporting induced pluripotent stem cell and cancer research.

Safe Harbor Statement

Certain statements contained herein and subsequent statements made by and on behalf of the Company, whether oral or written may contain "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Such forward looking statements are identified by words such as "intends," "anticipates," "believes," "expects" and "hopes" and include, without limitation, statements regarding the Company’s plan of business operations, product research and development activities, potential contractual arrangements, receipt of working capital, anticipated revenues and related expenditures. Factors that could cause actual results to differ materially include, among others, acceptability of the Company’s products in the market place, general economic conditions, receipt of additional working capital, the overall state of the biotechnology industry and other factors set forth in the Company’s filings with the Securities and Exchange Commission. Most of these factors are outside the control of the Company. Investors are cautioned not to put undue reliance on forward-looking statements. Except as otherwise required by applicable securities statutes or regulations, the Company disclaims any intent or obligation to update publicly these forward looking statements, whether as a result of new information, future events or otherwise.

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