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GeneNews Announces Issuance of Second Foundational U.S. Patent for Core Sentinel Principle Technology

Tuesday, February 16, 2010

Significantly expands scope of protection for proprietary platform technology that identifies actionable biomarkers relating to disease and health from blood

Toronto -- GeneNews Limited (TSX: GEN), a company focused on developing blood-based biomarker tests for the early detection of diseases and personalized health management, today announced that it has been granted a second U.S. patent for its core platform technology, the Sentinel Principle(R). U.S. Patent # 7,662,558, entitled "Method of profiling gene expression in a human subject." The patent covers the application of the Sentinel Principle in any health management context, including diagnosis, staging of disease, drug testing, monitoring response to treatment and biomarker screening.

"This issuance follows the October 2009 issuance of U.S. Patent # 7,598,031, which covers screening of blood for candidate biomarkers of any body state using large-scale gene expression profiling," said Dr. Heiner Dreismann, Lead Director and Interim CEO of GeneNews. "Together, these two patents form a strong foundation for our IP, protecting the application of our Sentinel Principle across a broad spectrum of human conditions and through all aspects of personalized health management."

"We believe that the Sentinel Principle has the potential to change the way that medicine is currently practiced," said Gailina Liew, President & Chief Operating Officer of GeneNews. "The issuance of this second U.S. patent significantly expands the scope of protection for this ground-breaking approach to identify clinically actionable biomarkers. It also enhances GeneNews' ability to realize additional commercial value through potential licensing arrangements, the pending issuance of additional patents which cover biomarker panels for specific clinical indications, and the continued development of our own pipeline of 'Sentry' products."

The Sentinel Principle, a platform technology discovered and developed by GeneNews, is based on the concept that all clinical conditions and body states, including those resulting from disease or in response to treatment, generate characteristic gene expression signatures in the blood as a result of the constant and dynamic physiological interaction of blood with the cells, tissues and organs of the human body. This technology is the basis of GeneNews' initial product, ColonSentry, the world's first blood test for colorectal cancer. ColonSentry was launched in Canada in 2008 and is poised to enter the New York and New Jersey markets in the second half of 2010 through GeneNews' exclusive partnership for these U.S. states with Enzo Clinical Labs. GeneNews' broad patent portfolio includes pending patents related to these foundational patents in diverse disease areas such as cancer, cardiovascular, neurological and inflammatory conditions.

About GeneNews

GeneNews is an emerging molecular diagnostics company focused on the application of functional genomics to enable early diagnosis and personalized health management based on disease-specific biomarkers. The Company has been granted two U.S. patents for its core platform technology, the Sentinel Principle, which has the power to detect and stage virtually any disease or medical condition from a simple blood sample. GeneNews is currently applying the Sentinel Principle in major areas with unmet clinical needs such as cancer, arthritis, cardiovascular disease and neurological disorders. GeneNews launched its first commercial product, ColonSentry, a blood-based test to assess an individual's risk for colorectal cancer, in Canada in 2008. The Company expects ColonSentry to be introduced to the New York and New Jersey markets, via GeneNews' exclusive partnership for these U.S. states with Enzo Clinical Labs, in the second half of 2010. For more information on GeneNews and ColonSentry, visit and

This press release contains forward-looking statements, which reflect the Company's current expectations regarding future events. The forward-looking statements involve risks and uncertainties. Actual events could differ materially from those projected herein. Investors should consult the Company's ongoing quarterly filings and annual reports for additional information on risks and uncertainties relating to these forward-looking statements. The reader is cautioned not to rely on these forward-looking statements. The Company disclaims any obligation to update these forward-looking statements.

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