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Entelos Granted Patent for Predictive Toxicology for Biological Systems

Friday, January 07, 2011

Foster City, CA -- Entelos, Inc. announced today that the U.S. Patent and Trademark Office has granted U.S. Patent No. 7,853,406 entitled “Predictive Toxicology for Biological Systems” to the Company. This method to identify a potential toxicity of a therapy in a biological system, modeling a plurality of biological processes of the biological system, further strengthens the Entelos® PhysioLab® platforms to more efficiently and predicatively assess toxicity.

“We are pleased to add this new patent to our extensive array of patents and technology. This patent is a key component in enabling us to use the PhysioLab platforms to predict and confirm pathways that lead to toxicity with therapeutic interventions,” stated Julie Thomas Goggin, President and CEO of Entelos. “Our biosimulation platforms, with their ability to conduct insightful ‘what if’ analyses, have already led to better decisions in R&D. This new diagnostic capability will further enable us to better inform the design of clinical trials, as well as to avoid the serious consequences of unanticipated toxicity, such as Drug Induced Liver Injury (DILI).”

DILI is the leading cause of liver failure in the United States and is also the single major adverse drug event that terminates drug development programs and results in regulatory actions leading to failed or stalled drug approvals, market withdrawals, usage restrictions, and warnings to physicians.

This newly patented method expands the way in which Entelos’ PhysioLab platforms can be utilized in the area of toxicity. This, in turn, can have a significant impact on patient safety as well as on the efficiency with which clinical trials are designed and effective, safe new medicines enter the market.

About Entelos

Entelos, Inc. is a life sciences company applying next-generation predictive technologies across multiple markets in R&D, healthcare, and finance in healthcare drug development technology, to dramatically lower the risk, time, and cost of bringing products to market. The Company's PhysioLab platforms, "virtual population" technology, and toxicology reference systems are highly predictive and they assist our customers, including global pharmaceutical, health-care, and consumer products companies, to develop safer and more effective drugs and personal care products. Entelos currently provides customized products, technology and research services in safety testing, arthritis, hypertension, cardiovascular diseases, asthma, obesity, diabetes, hematopoeisis (anemia), and central nervous system, cholesterol metabolism, skin sensitization, and personal care products. The Company is headquartered in Foster City, California.

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