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Senomyx Announces Issuance of a New U.S. Patent Covering the Human Taste Receptor That Responds to Sweet Taste

Wednesday, July 11, 2007

San Diego, CA -- Senomyx, Inc. (Nasdaq: SNMX), a leading company using proprietary technologies to discover and develop novel flavor ingredients for the packaged food and beverage industry, announced today the issuance by the U.S. Patent and Trademark Office of U.S. Patent No. 7,241, 880, "T1R Taste Receptors and Genes Encoding Same." The new patent contains broad claims covering the human T1R2 taste receptor, which responds to the taste of both natural and synthetic sweet compounds. The patent extends the intellectual property protection provided by Senomyx's previously issued U.S. Patent No. 6,955,887, "Use of T1R Hetero-Oligomeric Taste Receptor to Screen for Compounds that Modulate Taste Signaling" and U.S. Patent No. 7,223,551, "T1R3 Receptor Binding Assays For Identification of Taste Modulatory Compounds," which have broad-based claims that cover novel techniques for using the human sweet taste receptor as the basis for assay systems that are more efficient than traditional flavor discovery procedures.

"The human sweet taste receptor is composed of two subunits, hT1R2 and hT1R3," explained Mark Zoller, Ph.D., Senomyx's Chief Scientific Officer and Executive Vice President of Discovery and Development. "Senomyx's pioneering work in clarifying the structure and function of the human sweet taste receptor has led to issued patents covering the sequences that encode each of the subunits, as well as subunit variants. The patents also cover the use of the receptor subunits in assays designed to identify new flavor ingredients that enhance or impart sweet taste. Senomyx is using these proprietary assays to screen our expansive libraries of nearly half a million natural extracts and synthetic compounds in an effort to discover new sweet taste enhancers and high potency sweeteners."

Senomyx's Sweet Enhancer Program is intended to provide novel flavor ingredients that enhance the taste of natural and artificial sweeteners and enable a significant reduction of added sweeteners in foods and beverages. The Company's complementary High Potency Sweetener Program is focused on identifying novel low- or non-caloric natural high potency sweeteners that provide improved taste and physical properties compared to currently available products. The flavor ingredients resulting from these programs may have applications in multiple product categories such as confectionaries, cereal, ice cream, beverages, yogurt, desserts, spreads, and bakery products, each of which represents a sizeable commercial market opportunity.

"Senomyx is now the owner or exclusive licensee of 88 issued patents and 323 pending patent applications in the U.S., Europe, and elsewhere." said Kent Snyder, President and Chief Executive Officer of Senomyx. "We view our intellectual property portfolio as an important asset that helps the Company establish collaborative agreements with market-leading food and beverage companies. Senomyx currently has product discovery and development collaborations with seven of the world's foremost packaged food and beverage companies: Ajinomoto, Cadbury Schweppes, Campbell Soup Company, The Coca-Cola Company, Kraft Foods, Nestle, and Solae. We intend to continue to leverage Senomyx's proprietary technologies and capabilities to enter into additional partnerships with preeminent companies that are looking to gain a competitive advantage for their products."

About Senomyx, Inc.

Senomyx is a leading company using proprietary taste receptor-based assays, screening technologies and optimization chemistry to discover and develop novel flavors, flavor enhancers, and taste modulators for the packaged food and beverage industry. Senomyx's current programs focus on the development of these flavor ingredients in the savory, sweet, salt, and bitter areas. Senomyx has entered into product discovery and development collaborations with seven of the world's leading packaged food and beverage companies: Ajinomoto Co., Inc., Cadbury Schweppes, Campbell Soup Company, The Coca-Cola Company, Kraft Foods Global, Inc., Nestle SA, and Solae, LLC. For more information, please visit

Forward-Looking Statement Statements included in this press release that are not a description of fact are forward-looking statements, including, but not limited to, our ability to identify potential flavor ingredients, the product categories our products will address, the size of the commercial opportunity for our products, and plans for additional collaborations. The inclusion of forward-looking statements should not be regarded as a representation by us that any of our plans, projections or future financial, scientific or business objectives will be achieved. Our actual results may differ materially from any projected future results set forth in this release as a result of the risks and uncertainties inherent in our business including, without limitation, difficulties or delays in developing, testing, obtaining regulatory approval, producing and marketing our flavors, flavor enhancers, taste modulators and related technologies; whether we will be able to enter into additional collaborations; our ability to collect royalties under our collaborations; the progress and timing of our scientific programs; changes in the laws or regulations of the United States and other countries that could adversely affect our and our collaborators' ability to develop and commercialize our products; whether any of our collaborations will result in the discovery and development of novel flavor ingredients, enhance the nutritional profile of products incorporating them or otherwise enhance our market position; our ability to protect our intellectual property and proprietary technology and to maintain and enforce our patents and licensing arrangements with various third party licensors; our ability to define the scope and validity of patent protection for our products and technologies; competition from other companies and flavor manufacturers and other risks detailed in our Securities and Exchange Commission filings, including our Annual Report on Form 10-K for the fiscal year ended December 31, 2006 and our Quarterly Report on Form 10-Q for the period ended March 31, 2007. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. All forward-looking statements are qualified in their entirety by this cautionary statement and we undertake no obligation to revise or update this news release to reflect events or circumstances after the date hereof.

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